graph TD
  RAW["23andMe raw
643K SNP"]:::input
  S1["1 · ID Normalization"]:::seq
  S2["2 · Imputation
640K ➜ 30M+"]:::seq
  S3["3 · VEP Annotation
missense / splice"]:::seq
  S4["4 · ClinVar
clinical significance"]:::seq
  S5["5 · gnomAD
allele frequencies"]:::seq
  S6["6 · GWAS + PRS
800+ phenotypes"]:::seq
  S7["7 · PGx
PharmCAT + CPIC"]:::seq
  S8["8 · AI scores
CADD / AM / SpliceAI"]:::seq
  P9["9 · Ancestry
Admixture / PCA / Y / mtDNA"]:::par
  P10["10 · Nutrigenomics
LCT / MTHFR / FTO"]:::par
  P11["11 · Traits + sports
HIrisPlex / ACTN3"]:::par
  P12["12 · HLA typing
SNP2HLA"]:::par
  P13["13 · Carrier screening
ACMG SF v3.3 · 84 genes"]:::par
  R14["14 · UNIFIED REPORT"]:::result
  VAL["VALIDATION"]:::warn

  RAW --> S1 --> S2 --> S3
  S3 --> S4 --> S5 --> S6 --> S7 --> S8
  S3 --> P9
  RAW --> P9
  S2 --> P12
  S3 --> P10
  S3 --> P11
  S3 --> P13
  S8 --> R14
  P9 --> R14
  P10 --> R14
  P11 --> R14
  P12 --> R14
  P13 --> R14
  R14 --> VAL

  classDef input fill:#0a2a35,stroke:#00e5ff,stroke-width:2px,color:#00e5ff,font-weight:700
  classDef seq fill:#081e28,stroke:#1a6a80,color:#c0e8f0
  classDef par fill:#0a2015,stroke:#2a8844,color:#a0f0c0
  classDef result fill:#2a1e08,stroke:#ffaa00,stroke-width:2px,color:#ffcc66,font-weight:700
  classDef warn fill:#2a0e0e,stroke:#ff4444,stroke-width:2px,color:#ff7777,font-weight:700